The FGGY carbohydrate kinase family: insights into the evolution of functional specificities.

ABSTRACT: Function diversification in large protein families is a major mechanism driving expansion of cellular networks, providing organisms with new metabolic capabilities and thus adding to their evolutionary success. However, our understanding of the evolutionary mechanisms of functional diversity in such families is very limited, which, among many other reasons, is due to the lack of functionally well-characterized sets of proteins. Here, using the FGGY carbohydrate kinase family as an example, we built a confidently annotated reference set (CARS) of proteins by propagating experimentally verified functional assignments to a limited number of homologous proteins that are supported by their genomic and functional contexts. Then, we analyzed, on both the phylogenetic and the molecular levels, the

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC3245297 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature