The promoting vibration in human heart lactate dehydrogenase is a preferred vibrational channel.

ABSTRACT: We examine whether the rate-promoting vibration of lactate dehydrogenase is a preferred axis of thermal energy transfer. While it seems plausible that such a mechanistically important motion is also a favored direction of energy transfer, none of the previous studies of rate-promoting vibrations in enzymatic catalysis have addressed this question. It is equally likely that the promoting vibration, though catalytically important, has no different properties than any other axis in the protein. Resolution of this issue is important for two reasons: First, if energy is transferred along this axis in a preferred fashion, it shows that the protein is engineered in a way that transfers thermal energy into a motion that is coupled to the chemical step. Second, the discovery of a preferred directio

SUBMITTER: Davarifar A 

PROVIDER: S-EPMC3245336 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature