Early biventricular molecular responses to an acute myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) remains as one of the most common lethal diseases in the world and therefore it is necessary to understand its effect on molecular basis. Genome-wide microarray analysis provides us to predict potential biomarkers and signaling pathways for this purpose.

Objectives

The aim of this study is to understand the molecular basis of the immediate right ventricular cellular response to left ventricular AMI.

Material and methods

A rat model of left anterior descending coronary artery ligation was used to assess the effect of left ventricular AMI on both the right ventricle as a remote zone and the left ventricle as an ischemic/infarct zone. Microarray technology was applied to detect the gene expression. Gene Ontology and KEGG pathw

SUBMITTER: Erdal C 

PROVIDER: S-EPMC3245415 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature