Synthesis of an antiviral drug precursor from chitin using a saprophyte as a whole-cell catalyst.

ABSTRACT:

Background

Recent incidents, such as the SARS and influenza epidemics, have highlighted the need for readily available antiviral drugs. One important precursor currently used for the production of Relenza, an antiviral product from GlaxoSmithKline, is N-acetylneuraminic acid (NeuNAc). This substance has a considerably high market price despite efforts to develop cost-reducing (biotechnological) production processes. Hypocrea jecorina (Trichoderma reesei) is a saprophyte noted for its abundant secretion of hydrolytic enzymes and its potential to degrade chitin to its monomer N-acetylglucosamine (GlcNAc). Chitin is considered the second most abundant biomass available on earth and therefore an attractive raw material.

Results

In this study, we introduced two enzymes from bacte

SUBMITTER: Steiger MG 

PROVIDER: S-EPMC3245449 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature