Prediction of protein motions from amino acid sequence and its application to protein-protein interaction.

ABSTRACT:

Background

Structural flexibility is an important characteristic of proteins because it is often associated with their function. The movement of a polypeptide segment in a protein can be broken down into two types of motions: internal and external ones. The former is deformation of the segment itself, but the latter involves only rotational and translational motions as a rigid body. Normal Model Analysis (NMA) can derive these two motions, but its application remains limited because it necessitates the gathering of complete structural information.

Results

In this work, we present a novel method for predicting two kinds of protein motions in ordered structures. The prediction uses only information from the amino acid sequence. We prepared a dataset of the internal and externa

SUBMITTER: Hirose S 

PROVIDER: S-EPMC3245509 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature