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ABSTRACT: Objectives
The Relational and Item-Specific Encoding task (RISE) was designed to assess contributions of specific encoding and retrieval processes to episodic memory in schizophrenia. This manuscript describes how a cognitive neuroscience functional imaging paradigm was translated for clinical research.Methods
The RISE manipulates encoding by requiring participants to decide whether stimuli are "living/nonliving" (item-specific) or whether one stimulus fits inside the other (relational) and estimates familiarity (F) and recollection (R) by examining receiver operator characteristics (ROC) and assessing item and associative recognition. Two studies examined psychometric characteristics and tested the hypothesis that patients have differential deficits in relational vs item-s
SUBMITTER: Ragland JD
PROVIDER: S-EPMC3245591 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature