Adherens junction protein nectin-4 is the epithelial receptor for measles virus.

ABSTRACT: Measles virus is an aerosol-transmitted virus that affects more than 10 million children each year and accounts for approximately 120,000 deaths. Although it was long believed to replicate in the respiratory epithelium before disseminating, it was recently shown to infect initially macrophages and dendritic cells of the airways using signalling lymphocytic activation molecule family member 1 (SLAMF1; also called CD150) as a receptor. These cells then cross the respiratory epithelium and transport the infection to lymphatic organs where measles virus replicates vigorously. How and where the virus crosses back into the airways has remained unknown. On the basis of functional analyses of surface proteins preferentially expressed on virus-permissive human epithelial cell lines, here we identif

SUBMITTER: Muhlebach MD 

PROVIDER: S-EPMC3245798 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature