Changes in the plasma proteome follows chronic opiate administration in simian immunodeficiency virus infected rhesus macaques.

ABSTRACT:

Background

Substantive plasma proteomic changes follow lentiviral infection and disease pathobiology. We posit that such protein alterations are modified during drug abuse, further serving to affect the disease. To this end, we investigated the effect of opiate administration on the plasma proteome of Indian-strain rhesus monkeys infected with simian immunodeficiency virus (SIV) strain smm9.

Methods

Whole blood was collected at 7 weeks prior to and 1.4 and 49 weeks after viral infection. Viral load, CD4(+) T cell subsets, and plasma protein content were measured from monkeys that did or did not receive continuous opiate administrations. The plasma proteome was identified and quantified by isobaric tags for relative and absolute quantitation labeling (iTRAQ) and mass spectrom

SUBMITTER: Wiederin JL 

PROVIDER: S-EPMC3245805 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature