Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs.

ABSTRACT:

Aims/hypothesis

Evaluation of the association of 31 common single nucleotide polymorphisms (SNPs) with fasting glucose, fasting insulin, HOMA-beta cell function (HOMA-β), HOMA-insulin resistance (HOMA-IR) and type 2 diabetes in the Indian population.

Methods

We genotyped 3,089 sib pairs recruited in the Indian Migration Study from four cities in India (Lucknow, Nagpur, Hyderabad and Bangalore) for 31 SNPs in 24 genes previously associated with type 2 diabetes in European populations. We conducted within-sib-pair analysis for type 2 diabetes and its related quantitative traits.

Results

The risk-allele frequencies of all the SNPs were comparable with those reported in western populations. We demonstrated significant associations of CXCR4 (rs932206), CDKAL1 (rs7756992) a

SUBMITTER: Gupta V 

PROVIDER: S-EPMC3245821 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature