Ontology highlight
ABSTRACT:
SUBMITTER: Higa-Nakamine S
PROVIDER: S-EPMC3245925 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Nucleic acids research 20110908 1
Non-coding RNAs (ncRNAs) play key roles in diverse cellular activities, and efficient ncRNA function requires extensive posttranscriptional nucleotide modifications. Small nucleolar RNAs (snoRNAs) are a group of ncRNAs that guide the modification of specific nucleotides in ribosomal RNAs (rRNAs) and small nuclear RNAs. To investigate the physiological relevance of rRNA modification in vertebrates, we suppressed the expression of three snoRNAs (U26, U44 and U78), either by disrupting the host gen ...[more]