Detection of recombination events in bacterial genomes from large population samples.

ABSTRACT: Analysis of important human pathogen populations is currently under transition toward whole-genome sequencing of growing numbers of samples collected on a global scale. Since recombination in bacteria is often an important factor shaping their evolution by enabling resistance elements and virulence traits to rapidly transfer from one evolutionary lineage to another, it is highly beneficial to have access to tools that can detect recombination events. Multiple advanced statistical methods exist for such purposes; however, they are typically limited either to only a few samples or to data from relatively short regions of a total genome. By harnessing the power of recent advances in Bayesian modeling techniques, we introduce here a method for detecting homologous recombination events from who

SUBMITTER: Marttinen P 

PROVIDER: S-EPMC3245952 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature