Activation and role of the medial prefrontal cortex (mPFC) in extinction of ethanol-induced associative learning in mice.

ABSTRACT: Although the medial prefrontal cortex (mPFC) has been shown to be integrally involved in extinction of a number of associative behaviors, its role in extinction of alcohol (ethanol)-induced associative learning has received little attention. Previous reports have provided evidence supporting a role for the mPFC in acquisition and extinction of amphetamine-induced conditioned place preference (CPP) in rats, however, it remains unknown if this region is necessary for extinction of ethanol (EtOH)-induced associative learning in mice. Using immunohistochemical analysis of phosphorylated and unphosphorylated cAMP response element-binding protein (CREB), the current set of experiments first showed that the prelimbic (PL) and infralimbic (IL) subregions of the mPFC exhibited dynamic responses in

SUBMITTER: Groblewski PA 

PROVIDER: S-EPMC3246036 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature