Increased variance in germline allele-specific expression of APC associates with colorectal cancer.

ABSTRACT:

Background & aims

Germline variations in allele-specific expression (ASE) are associated with highly penetrant familial cancers, but their role in common sporadic cancers is unclear. ASE of adenomatous polyposis coli (APC) is associated with pathogenesis of familial adenomatous polyposis. We investigated whether moderate variations in ASE of APC contribute to common forms of colorectal cancer (CRC).

Methods

Denaturing high-performance liquid chromatography was used to analyze germline ASE of APC in blood samples from patients with CRC (cases, n = 53) and controls (n = 68). Means, medians, and variances of ASE were compared. Variants in the APC gene region also were analyzed.

Results

The distribution of ASE differed significantly between groups; cases had significantly

SUBMITTER: Curia MC 

PROVIDER: S-EPMC3246305 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature