Divergent synthetic approach to 6''-modified α-GalCer analogues.

ABSTRACT: A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6''-modified KRN7000 analogues.

SUBMITTER: Pauwels N 

PROVIDER: S-EPMC3246390 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature