Chronic insulin therapy reduces adipose tissue macrophage content in LDL-receptor-deficient mice.

ABSTRACT:

Aims/hypothesis

Insulin has anti-inflammatory effects in short-term experiments. However, the effects of chronic insulin administration on inflammation are unknown. We hypothesised that chronic insulin administration would beneficially alter adipose tissue inflammation and several circulating inflammatory markers.

Methods

We administered two forms of long-acting insulin, insulin glargine (A21Gly,B31Arg,B32Arg human insulin) and insulin detemir (B29Lys[ε-tetradecanoyl],desB30 human insulin), to LDL-receptor-deficient mice. After 8 weeks on a diet that causes obesity, hyperglycaemia, adipose tissue macrophage accumulation and atherosclerosis, the mice received subcutaneous glargine, detemir or NaCl (control) for 12 weeks. Serum amyloid A (SAA) and serum amyloid P (SAP), metabo

SUBMITTER: Yoon J 

PROVIDER: S-EPMC3246423 | biostudies-literature | 2011 May

REPOSITORIES: biostudies-literature