Extent of height variability explained by known height-associated genetic variants in an isolated population of the Adriatic coast of Croatia.

ABSTRACT:

Background

Human height is a classical example of a polygenic quantitative trait. Recent large-scale genome-wide association studies (GWAS) have identified more than 200 height-associated loci, though these variants explain only 2∼10% of overall variability of normal height. The objective of this study was to investigate the variance explained by these loci in a relatively isolated population of European descent with limited admixture and homogeneous genetic background from the Adriatic coast of Croatia.

Methodology/principal findings

In a sample of 1304 individuals from the island population of Hvar, Croatia, we performed genome-wide SNP typing and assessed the variance explained by genetic scores constructed from different panels of height-associated SNPs extracted from fi

SUBMITTER: Zhang G 

PROVIDER: S-EPMC3246488 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature