Presynaptic residual calcium and synaptic facilitation at hippocampal synapses of mice with altered expression of SNAP-25.

ABSTRACT: Paired pulse facilitation (PPF) is a form of short-term synaptic plasticity that results from an interaction of residual presynaptic Ca(2+) ([Ca(2+)](res)), number of release-competent vesicles, and the sensitivity of the vesicle release mechanisms to Ca(2+). While PPF is predominant at hippocampal Schaffer collateral-CA1 (SC-CA1) synapses, facilitation is greater in adult mice (designated Tkneo) that over express an isoform of the plasma membrane-targeted SNARE protein, SNAP-25a, which is normally predominantly expressed in juvenile animals. SNAP-25 is essential for action potential-dependent neuroexocytosis, yet the significance of the shift between the alternatively spliced variants SNAP-25a and SNAP-25b is not fully understood. This alteration of a key component of the protein machiner

SUBMITTER: Scullin CS 

PROVIDER: S-EPMC3246534 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature