Ontology highlight
ABSTRACT:
SUBMITTER: May D
PROVIDER: S-EPMC3246570 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Nature genetics 20111204 1
Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers. To generate an accurate genome-wide map of human heart enhancers, we used an epigenomic enhancer discovery approach and identified ∼6,200 candidate enhancer sequences directly from fetal and adult human heart tissue. Consistent with their predicted function, these elements were markedly enriched near genes implicated in heart development, funct ...[more]