Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs.

ABSTRACT:

Background

Many dichotomous traits for complex diseases are often involved more than one locus and/or associated with quantitative biomarkers or environmental factors. Incorporating these quantitative variables into linkage analysis as well as localizing two linked disease loci simultaneously could therefore improve the efficiency in mapping genes. We extended the robust multipoint Identity-by-Descent (IBD) approach with incorporation of covariates developed previously to simultaneously estimate two linked loci using different types of affected relative pairs (ARPs).

Results

We showed that the efficiency was enhanced by incorporating a quantitative covariate parametrically or non-parametrically while localizing two disease loci using ARPs. In addition to its help in identify

SUBMITTER: Chiu YF 

PROVIDER: S-EPMC3247820 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature