Excessive Dpp signaling induces cardial apoptosis through dTAK1 and dJNK during late embryogenesis of Drosophila.

ABSTRACT:

Background

To identify genes involved in the heart development of Drosophila, we found that embryos lacking raw function exhibited cardial phenotypes. raw was initially identified as a dorsal open group gene. The dorsal open phenotype was demonstrated to be resulted from the aberrant expression of decapentaplegic (dpp), a member of the tumor growth factor beta (TGF-β), signaling pathway. Despite the role of dpp in pattering cardioblasts during early embryogenesis of Drosophila have been demonstrated, how mutation in raw and/or excessive dpp signaling involves in the differentiating heart of Drosophila has not been fully elaborated at late stages.

Results

We show that raw mutation produced a mild overspecification of cardial cells at stage 14, but these overproduced cells wer

SUBMITTER: Yang SA 

PROVIDER: S-EPMC3247863 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature