Common polymorphisms in FMO1 are associated with nicotine dependence.

ABSTRACT:

Background

Cigarette smoking and other forms of tobacco use are the leading cause of preventable mortality in the world. A better understanding of the etiology of nicotine addiction may help to increase the success rate of cessation and to decrease the massive morbidity and mortality associated with smoking.

Methods

To identify genetic polymorphisms that contribute to nicotine dependence, our group undertook a genetic association study including three enzyme families that potentially influence nicotine metabolism: cytochrome P450 enzymes, flavin monooxygenases (FMOs), and UDP-glucuronosyl transferases.

Results

Several polymorphisms in FMO1 showed association in a discovery sample, and were tested in an independent replication sample. One polymorphism, rs10912765, show

SUBMITTER: Hinrichs AL 

PROVIDER: S-EPMC3248052 | biostudies-literature | 2011 Jul

REPOSITORIES: biostudies-literature