Global assessment of genomic variation in cattle by genome resequencing and high-throughput genotyping.

ABSTRACT:

Background

Integration of genomic variation with phenotypic information is an effective approach for uncovering genotype-phenotype associations. This requires an accurate identification of the different types of variation in individual genomes.

Results

We report the integration of the whole genome sequence of a single Holstein Friesian bull with data from single nucleotide polymorphism (SNP) and comparative genomic hybridization (CGH) array technologies to determine a comprehensive spectrum of genomic variation. The performance of resequencing SNP detection was assessed by combining SNPs that were identified to be either in identity by descent (IBD) or in copy number variation (CNV) with results from SNP array genotyping. Coding insertions and deletions (indels) were found t

SUBMITTER: Zhan B 

PROVIDER: S-EPMC3248099 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature