Intra-graft expression of genes involved in iron homeostasis predicts the development of operational tolerance in human liver transplantation.

ABSTRACT: Following organ transplantation, lifelong immunosuppressive therapy is required to prevent the host immune system from destroying the allograft. This can cause severe side effects and increased recipient morbidity and mortality. Complete cessation of immunosuppressive drugs has been successfully accomplished in selected transplant recipients, providing proof of principle that operational allograft tolerance is attainable in clinical transplantation. The intra-graft molecular pathways associated with successful drug withdrawal, however, are not well defined. In this study, we analyzed sequential blood and liver tissue samples collected from liver transplant recipients enrolled in a prospective multicenter immunosuppressive drug withdrawal clinical trial. Before initiation of drug withdrawal

SUBMITTER: Bohne F 

PROVIDER: S-EPMC3248302 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature