Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing.

ABSTRACT: Neovascularization is a critical determinant of wound-healing outcomes for deep burn injuries. We hypothesize that dextran-based hydrogels can serve as instructive scaffolds to promote neovascularization and skin regeneration in third-degree burn wounds. Dextran hydrogels are soft and pliable, offering opportunities to improve the management of burn wound treatment. We first developed a procedure to treat burn wounds on mice with dextran hydrogels. In this procedure, we followed clinical practice of wound excision to remove full-thickness burned skin, and then covered the wound with the dextran hydrogel and a dressing layer. Our procedure allows the hydrogel to remain intact and securely in place during the entire healing period, thus offering opportunities to simplify the management of bu

SUBMITTER: Sun G 

PROVIDER: S-EPMC3248550 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature