An exonic insertion within Tex14 gene causes spermatogenic arrest in pigs.

ABSTRACT:

Background

Male infertility is an increasing problem in all domestic species including man. Localization and identification of genes involved in defects causing male infertility provide valuable information of specific events in sperm development. Sperm development is a complex process, where diploid spermatogonia develop into haploid, highly specialized spermatozoa. Correct expression and function of various genes and their protein products are required for production of fertile sperm. We have identified an infertility defect in Finnish Yorkshire boars caused by spermatogenic arrest. The aim of this study was to locate the disease associated region using genome wide screen with the PorcineSNP60 Beadchip and identify the causal mutation by candidate gene approach.

Results

In

SUBMITTER: Sironen A 

PROVIDER: S-EPMC3248578 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature