A model study toward the total synthesis of N-deacetyllappaconitine.

ABSTRACT: [reaction: see text] A model study leading to the preparation of the AEF rings of N-deacetyllappaconitine is described. The conjugate addition to the alpha-alkyl cyclohexenone 10 proceeded with high diastereocontrol. The Mannich cyclization of 16 to 4 was accomplished by heating with Rexyn-300 and Na(2)SO(4).

SUBMITTER: Taber DF 

PROVIDER: S-EPMC3248817 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature