Associations of iron metabolism genes with blood manganese levels: a population-based study with validation data from animal models.

ABSTRACT:

Background

Given mounting evidence for adverse effects from excess manganese exposure, it is critical to understand host factors, such as genetics, that affect manganese metabolism.

Methods

Archived blood samples, collected from 332 Mexican women at delivery, were analyzed for manganese. We evaluated associations of manganese with functional variants in three candidate iron metabolism genes: HFE [hemochromatosis], TF [transferrin], and ALAD [δ-aminolevulinic acid dehydratase]. We used a knockout mouse model to parallel our significant results as a novel method of validating the observed associations between genotype and blood manganese in our epidemiologic data.

Results

Percentage of participants carrying at least one copy of HFE C282Y, HFE H63D, TF P570S, and ALAD K5

SUBMITTER: Claus Henn B 

PROVIDER: S-EPMC3248860 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature