ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression.

ABSTRACT:

Background

The genetic characterization of chronic lymphocytic leukemia cells correlates with the behavior, progression and response to treatment of the disease.

Design and methods

Our aim was to investigate the role of ATM gene alterations, their biological consequences and their value in predicting disease progression. The ATM gene was analyzed by denaturing high performance liquid chromatography and multiplex ligation probe amplification in a series of patients at diagnosis. The results were correlated with immunoglobulin gene mutations, cytogenetic abnormalities, ZAP-70 and CD38 expression, TP53 mutations, gene expression profile and treatment-free interval.

Results

Mutational screening of the ATM gene identified point mutations in 8/57 cases (14%). Multiplex liga

SUBMITTER: Guarini A 

PROVIDER: S-EPMC3248930 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature