Position 156 influences the peptide repertoire and tapasin dependency of human leukocyte antigen B*44 allotypes.

ABSTRACT:

Background

Polymorphic differences between donor and recipient human leukocyte antigen class I molecules can result in graft-versus-host disease due to distinct peptide presentation. As part of the peptide-loading complex, tapasin plays an important role in selecting peptides from the pool of potential ligands. Class I polymorphisms can significantly alter the tapasin-mediated interaction with the peptide-loading complex and although most class I allotypes are highly dependent upon tapasin, some are able to load peptides independently of tapasin. Several human leukocyte antigen B*44 allotypes differ exclusively at position 156 (B*44:02(156Asp), 44:03(156Leu), 44:28(156Arg), 44:35(156Glu)). From these alleles, only the high tapasin-dependency of human leukocyte antigen B*44:02 has b

SUBMITTER: Badrinath S 

PROVIDER: S-EPMC3248936 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature