Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects.

ABSTRACT:

Unlabelled

Gene-based association approach could be regarded as a complementary analysis to the single SNP association analysis. We meta-analyzed the findings from the gene-based association approach using the genome-wide association studies (GWAS) data from Chinese and European subjects, confirmed several well established bone mineral density (BMD) genes, and suggested several novel BMD genes.

Introduction

The introduction of GWAS has greatly increased the number of genes that are known to be associated with common diseases. Nonetheless, such a single SNP GWAS has a lower power to detect genes with multiple causal variants. We aimed to assess the association of each gene with BMD variation at the spine and hip using gene-based GWAS approach.

Methods

We studied 778 Ho

SUBMITTER: Cheung CL 

PROVIDER: S-EPMC3249198 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature