Ordered subset analysis identifies loci influencing lung cancer risk on chromosomes 6q and 12q.

ABSTRACT:

Background

Genetic susceptibility for cancer can differ substantially among families. We use trait-related covariates to identify a genetically homogeneous subset of families with the best evidence for linkage in the presence of heterogeneity.

Methods

We performed a genome-wide linkage screen in 93 families. Samples and data were collected by the familial lung cancer recruitment sites of the Genetic Epidemiology of Lung Cancer Consortium. We estimated linkage scores for each family by the Markov chain Monte Carlo procedure using SimWalk2 software. We used ordered subset analysis (OSA) to identify genetically homogenous families by ordering families based on a disease-associated covariate. We performed permutation tests to determine the relationship between the trait-related

SUBMITTER: Fang S 

PROVIDER: S-EPMC3249234 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature