The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
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ABSTRACT:
SUBMITTER: Mihaylova MM
PROVIDER: S-EPMC3249400 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Publications
The AMPK signalling pathway coordinates cell growth, autophagy and metabolism.
Mihaylova Maria M MM Shaw Reuben J RJ
Nature cell biology 20110902 9
One of the central regulators of cellular and organismal metabolism in eukaryotes is AMP-activated protein kinase (AMPK), which is activated when intracellular ATP production decreases. AMPK has critical roles in regulating growth and reprogramming metabolism, and has recently been connected to cellular processes such as autophagy and cell polarity. Here we review a number of recent breakthroughs in the mechanistic understanding of AMPK function, focusing on a number of newly identified downstre ...[more]
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