Biophysics of α-synuclein membrane interactions.

ABSTRACT: Membrane proteins participate in nearly all cellular processes; however, because of experimental limitations, their characterization lags far behind that of soluble proteins. Peripheral membrane proteins are particularly challenging to study because of their inherent propensity to adopt multiple and/or transient conformations in solution and upon membrane association. In this review, we summarize useful biophysical techniques for the study of peripheral membrane proteins and their application in the characterization of the membrane interactions of the natively unfolded and Parkinson's disease (PD) related protein, α-synuclein (α-syn). We give particular focus to studies that have led to the current understanding of membrane-bound α-syn structure and the elucidation of specific membrane pro

SUBMITTER: Pfefferkorn CM 

PROVIDER: S-EPMC3249522 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature