CSF levels of hypocretin-1 (orexin-A) peak during early infancy in humans.

ABSTRACT:

Study objectives

Hypocretin (orexin) is a unique neuropeptide involved in the consolidation of wakefulness and sleep. Although hypocretin-1 levels in the cerebrospinal fluid (CSF) are stable after infancy, how levels change in preterm and term human infants is unknown.

Design, patients, and setting

Hypocretin-1 levels were measured in CSF samples, obtained from 284 preterm (25-37 gestational weeks) and full-term infants in the first 4 months of life and 35 older children (ages 0.5-13 years), in a tertiary hospital.

Measurements and results

Detailed clinical and laboratory data were collected for each of the 319 participants. Based on that data, 108 neurologically intact children were selected (95 infants [43 preterm and 52 term] and 13 older children). CSF hypocretin-

SUBMITTER: Aran A 

PROVIDER: S-EPMC3250357 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature