Cerebellar globular cells receive monoaminergic excitation and monosynaptic inhibition from Purkinje cells.

ABSTRACT: Inhibitory interneurons in the cerebellar granular layer are more heterogeneous than traditionally depicted. In contrast to Golgi cells, which are ubiquitously distributed in the granular layer, small fusiform Lugaro cells and globular cells are located underneath the Purkinje cell layer and small in number. Globular cells have not been characterized physiologically. Here, using cerebellar slices obtained from a strain of gene-manipulated mice expressing GFP specifically in GABAergic neurons, we morphologically identified globular cells, and compared their synaptic activity and monoaminergic influence of their electrical activity with those of small Golgi cells and small fusiform Lugaro cells. Globular cells were characterized by prominent IPSCs together with monosynaptic inputs from the a

SUBMITTER: Hirono M 

PROVIDER: S-EPMC3250469 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature