Murine dendritic cells transcriptional modulation upon Paracoccidioides brasiliensis infection.

ABSTRACT: Limited information is available regarding the modulation of genes involved in the innate host response to Paracoccidioides brasiliensis, the etiologic agent of paracoccidioidomycosis. Therefore, we sought to characterize, for the first time, the transcriptional profile of murine bone marrow-derived dendritic cells (DCs) at an early stage following their initial interaction with P. brasiliensis. DCs connect innate and adaptive immunity by recognizing invading pathogens and determining the type of effector T-cell that mediates an immune response. Gene expression profiles were analyzed using microarray and validated using real-time RT-PCR and protein secretion studies. A total of 299 genes were differentially expressed, many of which are involved in immunity, signal transduction, transcripti

SUBMITTER: Tavares AH 

PROVIDER: S-EPMC3250510 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature