Association of the oncostatin m receptor gene polymorphisms with papillary thyroid cancer in the korean population.

ABSTRACT:

Objectives

To investigate the association between papillary thyroid cancer (PTC) and single nucleotide polymorphisms (SNPs) of oncostatin M receptor (OSMR) in the Korean population.

Methods

Retrospective case-control study was done. Eighty-five patients with PTC and 287 controls were studied. One missense SNP (rs2278329, Asp553Asn) and one promoter SNP (rs2292016, -100 G/T) of the OSMR gene were genotyped by direct sequencing. Genetic data were analyzed using the SNPStats, Helixtree, and SNPAnalyzer Pro. PTC patients were dichotomized and compared with respect to the clinicopathologic characteristics.

Results

There was no association between genotypes and allele frequencies of OSMR SNPs (rs2278329 and rs2292016) and PTC susceptibility. SNP rs2278329 was significantly

SUBMITTER: Hong IK 

PROVIDER: S-EPMC3250584 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature