Siblings with ischemic stroke study: results of a genome-wide scan for stroke loci.

ABSTRACT:

Background and purpose

Ischemic stroke has a strong familial component to risk. The Siblings With Ischemic Stroke Study (SWISS) is a genome-wide, family-based analysis that included use of imputed genotypes. The Siblings With Ischemic Stroke Study was conducted to examine the associations between single-nucleotide polymorphisms (SNPs) and risk of stroke and stroke subtypes within pairs.

Methods

The Siblings With Ischemic Stroke Study enrolled 312 probands with ischemic stroke from 70 US and Canadian centers. Affected siblings were ascertained by centers and confirmed by central record review; unaffected siblings were ascertained by telephone contact. Ischemic stroke was subtyped according to Trial of Org 10172 in Acute Stroke Treatment criteria. Genotyping was performed with

SUBMITTER: Meschia JF 

PROVIDER: S-EPMC3251509 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature