Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA.

ABSTRACT:

Background

Data from meta-analyses of genome-wide association studies provided evidence for an association of polymorphisms with body mass index (BMI), and gene expression results indicated a role of these variants in the hypothalamus. It was consecutively hypothesized that these associations might be evoked by a modulation of nutritional intake or energy expenditure.

Objective

It was our aim to investigate the association of these genetic factors with BMI in a large homogenous population-based sample to explore the association of these polymorphisms with lifestyle factors related to nutritional intake or energy expenditure, and whether such lifestyle factors could be mediators of the detected single-nucleotide polymorphism (SNP)-association with BMI. It was a further aim to

SUBMITTER: Holzapfel C 

PROVIDER: S-EPMC3251754 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature