Mid-gestational maternal free thyroxine concentration and offspring neurocognitive development at age two years.

ABSTRACT:

Context

Lower neurocognitive development scores at age 2 yr have been reported in association with euthyroid hypothyroxinemia during early pregnancy.

Objective

The objective of this study was to further explore this association with euthyroid hypothyroxinemia during early pregnancy.

Design

This was an observational, nested case-control study.

Setting

The study was conducted at physician offices and prenatal clinics throughout Maine.

Study subjects

Between May 2004 and March 2006, TSH was measured in 5734 women in conjunction with second-trimester Down syndrome screening. After completion of pregnancy, free T(4) was measured in stored second-trimester sera from euthyroid women (TSH 0.1-3.5 mIU/ml; n = 5560). Women with free T(4) at the third centile or le

SUBMITTER: Craig WY 

PROVIDER: S-EPMC3251941 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature