Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes.

ABSTRACT:

Background

Neuropeptide Y (NPY) is involved in stress regulation. Genetic variations predict plasma NPY and neural correlates of emotion and stress. We examined whether the functional NPY haplotype modulates stress-induced NPY and anxiety responses, and if plasma NPY stress responses are associated with substance dependence outcomes.

Methods

Thirty-seven treatment-engaged, abstinent substance dependent (SD) patients and 28 healthy controls (HCs) characterized on NPY diplotypes (HH: high expression; HLLL: intermediate/low expression) were exposed to stress, alcohol/drug cues and neutral relaxing cues, using individualized guided imagery, in a 3-session laboratory experiment. Plasma NPY, heart rate and anxiety were assessed. Patients were prospectively followed for 90-days pos

SUBMITTER: Xu K 

PROVIDER: S-EPMC3252459 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature