Ontology highlight
ABSTRACT:
SUBMITTER: Yildirim O
PROVIDER: S-EPMC3252821 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Cell 20111201 7
Numerous chromatin regulators are required for embryonic stem (ES) cell self-renewal and pluripotency, but few have been studied in detail. Here, we examine the roles of several chromatin regulators whose loss affects the pluripotent state of ES cells. We find that Mbd3 and Brg1 antagonistically regulate a common set of genes by regulating promoter nucleosome occupancy. Furthermore, both Mbd3 and Brg1 play key roles in the biology of 5-hydroxymethylcytosine (5hmC): Mbd3 colocalizes with Tet1 and ...[more]