Cannabinoid CB₂ receptor-mediated regulation of impulsive-like behaviour in DBA/2 mice.

ABSTRACT:

Background and purpose

This study evaluated gene expression differences between two mouse strains, characterized by opposite impulsivity-like traits and the involvement of the cannabinoid CB(2) receptor in the modulation of impulsivity.

Experimental approach

Behavioural tests were conducted to compare motor activity, exploration and novelty seeking, attention and cognitive and motor impulsivity (delayed reinforcement task: session duration 30 min; timeout 30 s) between A/J and DBA/2 mice. Expression of genes for dopamine D(2) receptors, CB(1) and CB(2) receptors were measured in the cingulate cortex (CgCtx), caudate-putamen (CPu), accumbens (Acc), amygdala (Amy) and hippocampus (Hipp). Involvement of CB(2) receptors in impulsivity was evaluated in DBA/2 mice with a CB(2) rec

SUBMITTER: Navarrete F 

PROVIDER: S-EPMC3252982 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature