Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation.

ABSTRACT:

Background

Pancreas cancer is one of most aggressive human cancers with the survival rate for patients with metastatic pancreas cancer at 5-6 months. The poor survival demonstrates a clear need for better target identification, drug development and new therapeutic strategies. Recent discoveries have shown that the role for Notch pathway is important in both development and cancer. Its contribution to oncogenesis also involves crosstalks with other growth factor pathways, such as Akt and its modulator, PTEN. The mounting evidence supporting a role for Notch in cancer promotion and survival suggests that targeting this pathway alone or in combination with other therapeutics represents a promising therapeutic strategy.

Results

Using a pancreas cancer tissue microarray, we noted

SUBMITTER: Vo K 

PROVIDER: S-EPMC3253061 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature