Reduced growth hormone secretion in obesity is associated with smaller LDL and HDL particle size.

ABSTRACT:

Objective

Reduced growth hormone (GH) secretion is observed in obesity and may contribute to increases in cardiovascular disease (CVD) risk. Lipoprotein characteristics including increased small dense low-density lipoprotein (LDL) particles are known independent risk factors for CVD. We hypothesized that reduced GH secretion in obesity would be associated with a more atherogenic lipid profile including increased small dense LDL particles.

Design

To evaluate this hypothesis, we studied 102 normal weight and obese men and women using standard GH stimulation testing to assess GH secretory capacity and performed comprehensive lipoprotein analyses including determination of lipoprotein particle size and subclass concentrations using proton NMR spectroscopy.

Results

Obese s

SUBMITTER: Makimura H 

PROVIDER: S-EPMC3253195 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature