Increased systemic inflammation overnight correlates with insulin resistance among children evaluated for obstructive sleep apnea.

ABSTRACT:

Purpose

Obstructive sleep apnea (OSA) in children is associated with obesity, insulin resistance, and elevated baseline inflammation as measured by high-sensitivity C-reactive protein (hsCRP). Our goal was to evaluate whether inflammation increases overnight among children suspected of having OSA and to determine whether worsened inflammation is associated with the degree of OSA severity, obesity, and/or insulin resistance.

Methods

Twenty-three children with clinical suspicion of OSA underwent a sleep study. Levels of hsCRP were tested the evening before and morning after the sleep study. Fasting insulin and glucose levels were measured from which the homeostasis model of insulin resistance (HOMA-IR) was calculated. Linear correlations were performed to evaluate relationship

SUBMITTER: Deboer MD 

PROVIDER: S-EPMC3253221 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature