Genetic variants, immune function, and risk of pre-eclampsia among American Indians.

ABSTRACT:

Problem

To determine the prevalence in an American Indian population of genetic variants with putative effects on immune function and determine if they are associated with pre-eclampsia (PE).

Method of study

In a study of 66 cases and 130 matched controls, six single nucleotide polymorphisms (SNP) with either previously demonstrated or postulated modulating effects on the immune system were genotyped. Allele frequencies and various genetic models were evaluated by conditional logistic regression in both univariate and multiply adjusted models.

Results

Although most genetic variants lacked evidence of association with PE, the minor allele of the CRP related, rs1205 SNP in a dominant model with adjustment for age at delivery, nulliparity, and body mass index, exhibited

SUBMITTER: Best LG 

PROVIDER: S-EPMC3253256 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature