Circadian dependence of infarct size and left ventricular function after ST elevation myocardial infarction.

ABSTRACT:

Rationale

In rodents, infarct size after ischemia/reperfusion exhibits a circadian dependence on the time of coronary occlusion. It is not known if a similar circadian dependence of infarct size occurs in humans.

Objective

To determine if humans exhibit a circadian dependence of infarct size in the setting of ST elevation myocardial infarction (STEMI).

Methods and results

A retrospective analysis of 1031 patients with STEMI referred for primary percutaneous coronary intervention with known ischemic times between 1 and 6 hours identified 165 patients with occluded arteries on presentation without evidence of preinfarction angina or collateral blood flow. Both ischemic duration and angiographic area at risk were not dependent on time of infarct onset. We observed that t

SUBMITTER: Reiter R 

PROVIDER: S-EPMC3253266 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature