The effect of chronic heart failure and type 2 diabetes on insulin-stimulated endothelial function is similar and additive.

ABSTRACT:

Aim

Chronic heart failure is associated with endothelial dysfunction and insulin resistance. The aim of this investigation was to study insulin-stimulated endothelial function and glucose uptake in skeletal muscles in patients with heart failure in comparison to patients with type 2 diabetes.

Methods

Twenty-three patients with systolic heart failure and no history of diabetes, seven patients with both systolic heart failure and type 2 diabetes, 19 patients with type 2 diabetes, and ten healthy controls were included in the study. Endothelial function was studied by venous occlusion plethysmography. Insulin-stimulated endothelial function was assessed after intra-arterial infusion of insulin followed by co-infusion with serotonin in three different dosages. Forearm glucose up

SUBMITTER: Falskov B 

PROVIDER: S-EPMC3253770 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature