Expression profiling in neuropsychiatric disorders: emphasis on glutamate receptors in bipolar disorder.

ABSTRACT: Functional genomics and proteomics approaches are being employed to evaluate gene and encoded protein expression changes with the tacit goal to find novel targets for drug discovery. Genome-wide association studies (GWAS) have attempted to identify valid candidate genes through single nucleotide polymorphism (SNP) analysis. Furthermore, microarray analysis of gene expression in brain regions and discrete cell populations has enabled the simultaneous quantitative assessment of relevant genes. The ability to associate gene expression changes with neuropsychiatric disorders, including bipolar disorder (BP), and their response to therapeutic drugs provides a novel means for pharmacotherapeutic interventions. This review summarizes gene and pathway targets that have been identified in GWAS stud

SUBMITTER: Ginsberg SD 

PROVIDER: S-EPMC3253885 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature